Long noncoding RNA ZMIZ1‐AS1 promotes gefitinib resistance via binding to hnRNPA1
نویسندگان
چکیده
To gain an insight into the molecular mechanisms of gefitinib resistance in nonsmall cell lung cancer, we screened out long noncoding RNA related to through microarray data gefitinib-sensitive and resistant cells. lncRNA ZMIZ1-AS1 was significantly upregulated HCC827/GR cells by screening data. Further real-time-qPCR results were consistent with Cell viability assay flow cytometry showed that influenced sensitivity gefitinib. pull-down demonstrated hnRNPA1 a specific binding protein for ZMIZ1-AS1. Our help reveal role mechanism secondary provide new therapeutic target therapy.
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ژورنال
عنوان ژورنال: Precision medical sciences
سال: 2021
ISSN: ['2642-2514']
DOI: https://doi.org/10.1002/prm2.12051